Complicated CR. Sephiroth would have very complicated CR with sciency types post-Awakening. And he does speak Science fluently; he never seems to have any trouble in the games understanding project notes and the like.

Seth would probably be more predisposed to the hard sciences, with a tendency towards engineering. He would happily discuss various disciplines even though his majors are PoliSci and Peace/Conflict Studies.

And Kurama/Shuuichi would absolutely be happy to work with his chem teacher, extra discussion and practice never hurt any teenager's grades.